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Prevention and Control. Programs aimed at the eradication of a specific disease on a national or even international scale have received a very mixed reception among health professionals. The complex and hugely expensive effort to eradicate human malaria must ultimately be termed a failure. This experience tended to make health planners leery of such seemingly grandiose undertakings. Then came the remarkable success of the global campaign to eradicate smallpox and the enthusiasm for such a final solution was rekindled. Now we have another such effort that has garnered the support of a large number of countries, programs, and individuals. The possibility that Guinea worm disease or dracunculiasis can be eradicated from all endemic foci has engendered a remarkable level of international cooperation that may bring about this laudable goal within the foreseeable future. The first paper in this issue (see page 529) provides some interesting and valuable insights into the process involved in the development of the Nigerian program to eradicate dracunculiasis.