Placental Pathology in Plasmodium berghei-Infected Rats

Tatsuya Tegoshi Institute of Pathology, Case Western Reserve University, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaii, Cleveland, Ohio

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Robert S. Desowitz Institute of Pathology, Case Western Reserve University, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaii, Cleveland, Ohio

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Keith G. Pirl Institute of Pathology, Case Western Reserve University, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaii, Cleveland, Ohio

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Yoshimasa Maeno Institute of Pathology, Case Western Reserve University, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaii, Cleveland, Ohio

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Masamichi Aikawa Institute of Pathology, Case Western Reserve University, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaii, Cleveland, Ohio

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DOI:
https://doi.org/10.4269/ajtmh.1992.47.643
Volume/Issue:
Volume 47: Issue 5
Page(s):
643–651
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The pathologic changes in placentae of pregnant rats infected with Plasmodium berghei at different stages of gestation were studied using light and electron microscopy and immunohistochemistry. The major changes observed were thickening and duplication of the trophoblastic basement membrane, and accumulation of parasitized erythrocytes and occasional mononuclear cells in the maternal blood space. Immunohistochemical examination of nine placentae revealed that six stained positively for IgG, two for IgM, and four for P. berghei antigen. No C3 deposition was detected. The findings in this study indicate that the variable parasitologic-clinical course from benign to fatal of P. berghei infection in pregnant rats makes it a potentially valuable model of human gestational malaria infection.

Author Notes

Copyright:
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene 1992
Published Online:
Nov 1992
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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