Plasmids in Salmonella Typhi in Lima, Peru, 1987–1988: Epidemiology and Lack of Association with Severity of Illness or Clinical Complications

Mark J. Finch Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Division of Geographic Medicine, Department of Medicine, and Center for Vaccine Development, University of Maryland School of Medicine, Lima, Peru

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Augusto Franco Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Division of Geographic Medicine, Department of Medicine, and Center for Vaccine Development, University of Maryland School of Medicine, Lima, Peru

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Eduardo Gotuzzo Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Division of Geographic Medicine, Department of Medicine, and Center for Vaccine Development, University of Maryland School of Medicine, Lima, Peru

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Carlos Carrillo Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Division of Geographic Medicine, Department of Medicine, and Center for Vaccine Development, University of Maryland School of Medicine, Lima, Peru

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Luis Benavente Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Division of Geographic Medicine, Department of Medicine, and Center for Vaccine Development, University of Maryland School of Medicine, Lima, Peru

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Steven S. Wasserman Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Division of Geographic Medicine, Department of Medicine, and Center for Vaccine Development, University of Maryland School of Medicine, Lima, Peru

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Myron M. Levine Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Division of Geographic Medicine, Department of Medicine, and Center for Vaccine Development, University of Maryland School of Medicine, Lima, Peru

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J. Glenn Morris Jr Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Division of Geographic Medicine, Department of Medicine, and Center for Vaccine Development, University of Maryland School of Medicine, Lima, Peru

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DOI:
https://doi.org/10.4269/ajtmh.1992.47.390
Volume/Issue:
Volume 47: Issue 3
Page(s):
390–396
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A prospective study was conducted to better characterize the epidemiology of plasmid-bearing strains of Salmonella typhi in an endemic area of Lima, Peru, and to determine if plasmids were associated with specific manifestations of typhoid fever. Of 228 S. typhi isolated from patients at Cayetano Heredia University Hospital in Lima during 1987–1988, 76 (33%) contained plasmids. Ten different plasmid profiles were identified, with ten distinct plasmids present within these profiles. There was significant temporal clustering of isolates having common plasmid profiles. Two plasmids (both from the same isolate) carried antibiotic resistance genes. Two cryptic plasmids with approximate sizes of 55 and 65 kilobases (kb) appeared to be closely related, based on restriction endonuclease digestions and Southern blot analysis. An ampicillin resistance plasmid from a 1989 patient isolate differed by only a single restriction fragment from the cryptic 65-kb plasmid. No association was found between any plasmid or plasmid profile and severity or clinical manifestations of disease.

Author Notes

Copyright:
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene 1992
Published Online:
Sep 1992
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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