Outbreak of Fatal Illness among Captive Macaques in the Philippines Caused by an Ebola-Related Filovirus

Curtis G. Hayes U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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James P. Burans U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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Thomas G. Ksiazek U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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Rennie A. Del Rosario U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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Mary Elizabeth G. Miranda U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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Corazon R. Manaloto U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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Agnes B. Barrientos U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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Celestina G. Robles U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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Manuel M. Dayrit U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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Clarence J. Peters U.S. Naval Medical Research Unit No. 2, U.S. Army Medical Research Institute of Infectious Diseases, Field Epidemiology Training Program, Philippine Department of Health, Research Institute for Tropical Medicine, Philippine Department of Health, Manila, The Philippines

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DOI:
https://doi.org/10.4269/ajtmh.1992.46.664
Volume/Issue:
Volume 46: Issue 6
Page(s):
664–671
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Following the detection of an Ebola-like virus in cynomolgus macaques recently imported into the United States from The Philippines, studies were initiated to document transmission at export facilities located in the latter country. At one export facility, 52.8% of 161 monkeys that died over a 2.5-month period were shown to be infected with this virus using an enzyme-linked immunosorbent assay to detect antigen in liver homogenates. A case fatality rate of 82.4% was documented for the infected monkeys. The initial anti-viral antibody prevalence among the captive macaques at this facility was 25.9% (indirect fluorescent antibody titer ≥ 1:16). Followup documented infection of 24.4% of initially seronegative animals and 8.7% of initially seropositive monkeys. Being held in a gang cage versus a single cage was found to be a significant risk factor for subsequent virus infection, and the presence of IFA antibody was shown to predict protection. This study documents unequivocally for the first time the presence of an Ebola-related filovirus in Asia.

Author Notes

Copyright:
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene 1992
Published Online:
Jun 1992
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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