Ultrasonographical Investigation of Periportal Fibrosis in Children with Schistosoma mansoni Infection: Reversibility of Morbidity Twenty-Three Months after Treatment with Praziquantel

Ekkehard Doehring-Schwerdtfeger Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Ekkehard Doehring-Schwerdtfeger in
Current site
Google Scholar
PubMed Close
,
Ibrahim M. Abdel-Rahim Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Ibrahim M. Abdel-Rahim in
Current site
Google Scholar
PubMed Close
,
Rudiger Kardorff Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Rudiger Kardorff in
Current site
Google Scholar
PubMed Close
,
Christoph Kaiser Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Christoph Kaiser in
Current site
Google Scholar
PubMed Close
,
Doris Franke Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Doris Franke in
Current site
Google Scholar
PubMed Close
,
Jens Schlake Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Jens Schlake in
Current site
Google Scholar
PubMed Close
,
Joachim Richter Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Joachim Richter in
Current site
Google Scholar
PubMed Close
,
Mamoun Elsheikh Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Mamoun Elsheikh in
Current site
Google Scholar
PubMed Close
,
Qurashi Mohamed-Ali Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Qurashi Mohamed-Ali in
Current site
Google Scholar
PubMed Close
, and
Jochen H. H. Ehrich Institute of Medical Parasitology, University of Bonn, Faculty of Medicine, University of Gezira, Kinderklinik, Medizinische Hochschule, Division of Tropical Pediatrics, Children's Hospital, University of Heidelberg, Martin Luther Krankenhaus Berlin, Sultan Qaboos University, Al-Khod, Bonn, Germany

Search for other papers by Jochen H. H. Ehrich in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1992.46.409
Volume/Issue:
Volume 46: Issue 4
Page(s):
409–415
Restricted access
Get Permissions

In February 1987, 322 Sudanese school children were diagnosed for Schistosoma mansoni infection and treated randomly with praziquantel (either 20 mg/kg or 40 mg/kg body weight). A followup of these subjects was carried out in January 1989. This treatment resulted in a substantial reduction of egg output. Patients underwent complete abdominal ultrasonography and periportal fibrosis of the liver was graded into three degrees of severity. The proportion of patients with periportal fibrosis decreased from 36.6% in February 1987 to 21.7% in January 1989. At the time of followup, higher grades of periportal fibrosis (grades II and III) were encountered in only 4.3% and 0.3% of these patients, respectively, compared with 21.1% and 5.9%, respectively, before therapy. This was paralleled by a significant decrease in hepatomegaly from 10.9% to 7% of the patients. In contrast, the rate of splenomegaly showed a slight increase during the period of observation. The different dosage regimens of praziquantel did not result in a significantly different reversibility of periportal fibrosis or a decrease in egg excretion. The reversibility of specific liver lesions 23 months after antischistosomal therapy with praziquantel was substantial. The improvement was greater at 23 months than that obtained seven months after treatment.

Author Notes

Copyright:
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene 1992
Published Online:
Apr 1992
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637

Expert Committee on Hepatitis

First Report. World Health Organization Technical Report Series No. 62 (Available also in French). 26 pp. Geneva, W.H.O., Palais des Nations. March, 1953. Price 1/6, $0.20, Fr. fr. 65.-; Sw. fr. 0.80

Past two years Past Year Past 30 Days
Abstract Views 1839 1403 239
Full Text Views 31 14 6
PDF Downloads 21 6 1
 

 

 

 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save