Malaria continues to be of enormous importance in various areas of the developing tropics. The first four papers in this issue are concerned with the subject of therapy for this disease. Two reports by Brasseur and colleagues address the problem of resistant strains of Plasmodium falciparum in Cameroon. It is interesting that the prevalence of chloroquine- and quinine-resistant isolates has remained essentially stable since the rapid emergence of this problem in 1985. The second of the two papers confirms the existence of mefloquine resistance in the country and correlates this phenomenon with the previous loss of quinine sensitivity in the same area. On page 15 is a report from Chinese colleagues of a new herbal agent, Daphnetin, with anti-malarial activity. The fourth paper in this issue presents the results of a clinical investigation on the impact of chloroquine prophylaxis during pregnancy on infant birthweight. In this study there was no significant difference in birthweights between treated and control groups.