Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 567 250 9
Full Text Views 25 7 0
PDF Downloads 20 7 0
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Daphnetin: a Novel Antimalarial Agent with in Vitro and in Vivo Activity

Ying-Zi YangDepartment of Microbiology, City University of New York Medical School, Department of Biochemistry, Institute of Basic Medical Sciences and Department of Hematology, Peking Union Medical School, New York, New York, People's Republic of China

Search for other papers by Ying-Zi Yang in
Current site
Google Scholar
PubMedClose
,
Allen RanzDepartment of Microbiology, City University of New York Medical School, Department of Biochemistry, Institute of Basic Medical Sciences and Department of Hematology, Peking Union Medical School, New York, New York, People's Republic of China

Search for other papers by Allen Ranz in
Current site
Google Scholar
PubMedClose
,
Hua-Zhen PanDepartment of Microbiology, City University of New York Medical School, Department of Biochemistry, Institute of Basic Medical Sciences and Department of Hematology, Peking Union Medical School, New York, New York, People's Republic of China

Search for other papers by Hua-Zhen Pan in
Current site
Google Scholar
PubMedClose
,
Zhi-Nan ZhangDepartment of Microbiology, City University of New York Medical School, Department of Biochemistry, Institute of Basic Medical Sciences and Department of Hematology, Peking Union Medical School, New York, New York, People's Republic of China

Search for other papers by Zhi-Nan Zhang in
Current site
Google Scholar
PubMedClose
,
Xie-Bin LinDepartment of Microbiology, City University of New York Medical School, Department of Biochemistry, Institute of Basic Medical Sciences and Department of Hematology, Peking Union Medical School, New York, New York, People's Republic of China

Search for other papers by Xie-Bin Lin in
Current site
Google Scholar
PubMedClose
, and
Steven R. MeshnickDepartment of Microbiology, City University of New York Medical School, Department of Biochemistry, Institute of Basic Medical Sciences and Department of Hematology, Peking Union Medical School, New York, New York, People's Republic of China

Search for other papers by Steven R. Meshnick in
Current site
Google Scholar
PubMedClose
View More View Less
DOI:
https://doi.org/10.4269/ajtmh.1992.46.15
Volume/Issue:
Volume 46: Issue 1
Page(s):
15–20
Restricted access
Get Permissions

Daphnetin is a dihydroxycoumarin that is being used in China for the treatment of coagulation disorders. It is also a chelator and an antioxidant. In vitro, daphnetin causes a 50% inhibition (IC50) of 3H-hypoxanthine incorporation by Plasmodium falciparum at concentrations between 25 and 40 µM. Several related compounds, such as scopoletin, 2, 3-dihydroxybenzoic acid and 3, 4-dihydroxybenzoic acid show no inhibitory activity. The antimalarial activity of daphnetin is inhibited by the addition of iron. Daphnetin does not appear to be an oxidant drug, since it does not spontaneously generate superoxide in vitro. However, it does alkylate bovine serum albumin when incubated in the presence of iron. In vivo, daphnetin significantly prolongs survival of P. yoelli—infected mice.
Copyright:
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene 1992
Published Online:
Jan 1992
Save