Acute Fatal Trypanosoma Cruzi Meningoencephalitis in a Human Immunodeficiency Virus-Positive Hemophiliac Patient

Marcelo Simao FerreiraCentro de Ciencias Biomedicas, Universidade Federal de Uberlandia, Faculdade de Medicina do Triangulo Mineiro, Uberlandia, Brazil

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Sergio De Andrade NishiokaCentro de Ciencias Biomedicas, Universidade Federal de Uberlandia, Faculdade de Medicina do Triangulo Mineiro, Uberlandia, Brazil

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Ademir RochaCentro de Ciencias Biomedicas, Universidade Federal de Uberlandia, Faculdade de Medicina do Triangulo Mineiro, Uberlandia, Brazil

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Arnaldo Moreira SilvaCentro de Ciencias Biomedicas, Universidade Federal de Uberlandia, Faculdade de Medicina do Triangulo Mineiro, Uberlandia, Brazil

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Rimarcs G. FerreiraCentro de Ciencias Biomedicas, Universidade Federal de Uberlandia, Faculdade de Medicina do Triangulo Mineiro, Uberlandia, Brazil

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Wilson OlivierCentro de Ciencias Biomedicas, Universidade Federal de Uberlandia, Faculdade de Medicina do Triangulo Mineiro, Uberlandia, Brazil

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Sebastiao Tostes JrCentro de Ciencias Biomedicas, Universidade Federal de Uberlandia, Faculdade de Medicina do Triangulo Mineiro, Uberlandia, Brazil

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A 37-year-old hemophiliac patient with known, asymptomatic human immunodeficiency virus infection and chronic Chagas' disease was admitted to the hospital complaining of fever and headache. A computed tomographic scan revealed multiple ring-enhancing lesions in both cerebral hemispheres. No antibodies to Trypanosoma cruzi were found in the cerebrospinal fluid. Treatment for toxoplasmosis of the central nervous system, which was considered the most likely diagnosis, was instituted, but the patient died after progressive neurologic deterioration. An autopsy revealed severe meningoencephalitis caused by T. cruzi.

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