Comparison of European Isolates of Viruses causing Hemorrhagic Fever with Renal Syndrome by a Neutralization Test

Bo Niklasson Department of Virology, National Bacteriological Laboratory, National Defense Research Establishment, Department of Virology, Karolinska Institute, Hemorrhagic Fever Laboratory, Institute of Poliomyelitis and Viral Encephalitides, Academy of Medical Sciences, Stockholm, Sweden

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Mari Jonsson Department of Virology, National Bacteriological Laboratory, National Defense Research Establishment, Department of Virology, Karolinska Institute, Hemorrhagic Fever Laboratory, Institute of Poliomyelitis and Viral Encephalitides, Academy of Medical Sciences, Stockholm, Sweden

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Ake Lundkvist Department of Virology, National Bacteriological Laboratory, National Defense Research Establishment, Department of Virology, Karolinska Institute, Hemorrhagic Fever Laboratory, Institute of Poliomyelitis and Viral Encephalitides, Academy of Medical Sciences, Stockholm, Sweden

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Jan Horling Department of Virology, National Bacteriological Laboratory, National Defense Research Establishment, Department of Virology, Karolinska Institute, Hemorrhagic Fever Laboratory, Institute of Poliomyelitis and Viral Encephalitides, Academy of Medical Sciences, Stockholm, Sweden

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Evgeni Tkachenko Department of Virology, National Bacteriological Laboratory, National Defense Research Establishment, Department of Virology, Karolinska Institute, Hemorrhagic Fever Laboratory, Institute of Poliomyelitis and Viral Encephalitides, Academy of Medical Sciences, Stockholm, Sweden

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DOI:
https://doi.org/10.4269/ajtmh.1991.45.660
Volume/Issue:
Volume 45: Issue 6
Page(s):
660–665
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Different virus isolates causing hemorrhagic fever with renal syndrome (HFRS) were compared using a neutralization test. Patient convalescent sera and antisera prepared in rabbits were used to compare Puumala-related Hantavirus isolates from Finland, Sweden, Belgium, and the USSR. The majority of European isolates were indistinguishable from each other using both homologous rabbit antisera and patient convalescent sera. The European isolates of HFRS were also compared with prototype Hantaan (the etiologic agent of Korean hemorrhagic fever). The one-way cross-reaction between the Hantaan and Puumala viruses, previously described using human convalescent sera tested by indirect immunofluorescence and immunoprecipitation, was also seen by the neutralization test.

Author Notes

Copyright:
Copyright © 1991 by The American Society of Tropical Medicine and Hygiene 1991
Published Online:
Dec 1991
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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