Characterization of Naturally Acquired Antibody Responses to a Recombinant Fragment from the N-Terminus of Plasmodium Falciparum Glycoprotein 195

Arthur E. Brown Department of Immunology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Department of Immunology, Walter Reed Army Institute of Research, Smith, Kline and Beckman Laboratories, King of Prussia, Bangkok, Thailand

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H. Kyle Webster Department of Immunology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Department of Immunology, Walter Reed Army Institute of Research, Smith, Kline and Beckman Laboratories, King of Prussia, Bangkok, Thailand

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Jeffrey A. Lyon Department of Immunology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Department of Immunology, Walter Reed Army Institute of Research, Smith, Kline and Beckman Laboratories, King of Prussia, Bangkok, Thailand

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Alan W. Thomas Department of Immunology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Department of Immunology, Walter Reed Army Institute of Research, Smith, Kline and Beckman Laboratories, King of Prussia, Bangkok, Thailand

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Barnyen Permpanich Department of Immunology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Department of Immunology, Walter Reed Army Institute of Research, Smith, Kline and Beckman Laboratories, King of Prussia, Bangkok, Thailand

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Mitchell Gross Department of Immunology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Department of Immunology, Walter Reed Army Institute of Research, Smith, Kline and Beckman Laboratories, King of Prussia, Bangkok, Thailand

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DOI:
https://doi.org/10.4269/ajtmh.1991.45.567
Volume/Issue:
Volume 45: Issue 5
Page(s):
567–573
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Antibody responses to the glycoprotein precursor of the major merozoite surface antigens of Plasmodium falciparum (gp195) were investigated in acutely infected Thai adults. Specific IgG antibody was assayed by enzyme-linked immunosorbent assay using a recombinant fragment derived from the N-terminal region of gp195 as the capture antigen. Two control groups were found to be without significant cross-reacting antibody. Among occupationally exposed soldiers, 84 of 85 men developed positive antibody responses during acute falciparum malaria. Mean antibody levels began to increase at the time of diagnosis, peaking, often at high titers, within two weeks, and then decreased with an initial serum half-life of less than one month. The high frequency of gp195 antibody responses underscores a potential role in serodiagnosis, whereas the dynamic nature of the response suggests that a rigorous schedule of prospective serum sampling will be required to accurately assess the relationship between these antibodies and protection.

Author Notes

Copyright:
Copyright © 1991 by The American Society of Tropical Medicine and Hygiene 1991
Published Online:
Nov 1991
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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