Hypnozoites of Plasmodium Simiovale

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  • Tulane Regional Primate Research Center, Malaria Branch, Division of Parasitic Diseases, Center for Infectious Disease, Centers for Disease Control, Division of National Hansen's Disease Programs, USPHS Hospital, Covington, Louisiana, Georgia
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Hypnozoites of Plasmodium simiovale were detected in liver biopsies from a rhesus monkey (Macaca mulatta) inoculated eight days previously with sporozoites from heavily infected anopheline mosquitoes. The tissue forms, 6µ in diameter, were found within the cytoplasm of hepatic parenchymal cells by immunofluorescence and restained with Giemsa. This is the first report of latent, pre-erythrocytic stages from an ovale-type relapsing malaria.