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Efficacy of Ivermectin for Control of Microfilaremia Recurring after Treatment with Diethylcarbamazine
I. Clinical and Parasitologic Observations
Zheng Huijun
Zheng Huijun
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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Willy F. Piessens
Willy F. Piessens
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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Tao Zhenghou
Tao Zhenghou
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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Cheng Wenfang
Cheng Wenfang
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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Wang Shihai
Wang Shihai
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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Cheng Shizhi
Cheng Shizhi
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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Ye Yangming
Ye Yangming
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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Luo Laifeng
Luo Laifeng
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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Chen Xiaorui
Chen Xiaorui
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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Gan Genbao
Gan Genbao
Guizhou Provincial Institute of Parasitic Diseases and Guizhou Provincial Institute of Pharmacology and Drug Control, Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations, Harvard School of Public Health, Guiyang, Guizhou, People's Republic of China
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We compared the efficacy of a single dose of ivermectin with that of a standard course of diethylcarbamazine (DEC) for the control of microfilaremia in 60 patients with bancroftian filariasis who had developed recurrent microfilaremia after each of three or more prior treatments with DEC. The study was done as a randomized, double-blind trial. Complete, but in some cases, transient clearance of microfilaremia was observed in both treatment groups. At one year, recurrent microfilaremia was present in seven patients treated with ivermectin and in five treated with DEC. Pretreatment levels of microfilaremia were significantly higher in patients who relapsed within one year after treatment than in those who remained amicrofilaremic. Side effects with both treatments were common, but mild. Febrile reactions were more frequent in the ivermectin group; localized reactions consistent with a flare-up of acute filarial disease occurred mostly in the DEC group. We conclude that ivermectin is an effective and practical alternative to DEC for treatment of recurrent microfilaremia due to bancroftian filariasis.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 385 | 198 | 13 |
| Full Text Views | 26 | 2 | 0 |
| PDF Downloads | 31 | 4 | 0 |