Polyclonal B-Lymphocyte Stimulation in Human Malaria and its Association with Ongoing Parasitemia

Dalma Maria Banic World Health Organization Collaborating Centre for Research and Training in Immunology of Parasitic Diseases, Oswaldo Cruz Institute, Infectious Diseases Service, Faculty of Medicine, Federal University of Rio de Janeiro, Barros Barreto Hospital, Evandro Chagas Hospital, Rio de Janeiro, Brazil

Search for other papers by Dalma Maria Banic in
Current site
Google Scholar
PubMed Close
,
Fernando Sergio Viana-Martins World Health Organization Collaborating Centre for Research and Training in Immunology of Parasitic Diseases, Oswaldo Cruz Institute, Infectious Diseases Service, Faculty of Medicine, Federal University of Rio de Janeiro, Barros Barreto Hospital, Evandro Chagas Hospital, Rio de Janeiro, Brazil

Search for other papers by Fernando Sergio Viana-Martins in
Current site
Google Scholar
PubMed Close
,
Jose Maria de Souza World Health Organization Collaborating Centre for Research and Training in Immunology of Parasitic Diseases, Oswaldo Cruz Institute, Infectious Diseases Service, Faculty of Medicine, Federal University of Rio de Janeiro, Barros Barreto Hospital, Evandro Chagas Hospital, Rio de Janeiro, Brazil

Search for other papers by Jose Maria de Souza in
Current site
Google Scholar
PubMed Close
,
Thiodimo de CastroPeixoto World Health Organization Collaborating Centre for Research and Training in Immunology of Parasitic Diseases, Oswaldo Cruz Institute, Infectious Diseases Service, Faculty of Medicine, Federal University of Rio de Janeiro, Barros Barreto Hospital, Evandro Chagas Hospital, Rio de Janeiro, Brazil

Search for other papers by Thiodimo de CastroPeixoto in
Current site
Google Scholar
PubMed Close
, and
Claudio Daniel-Ribeiro World Health Organization Collaborating Centre for Research and Training in Immunology of Parasitic Diseases, Oswaldo Cruz Institute, Infectious Diseases Service, Faculty of Medicine, Federal University of Rio de Janeiro, Barros Barreto Hospital, Evandro Chagas Hospital, Rio de Janeiro, Brazil

Search for other papers by Claudio Daniel-Ribeiro in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1991.44.571
Volume/Issue:
Volume 44: Issue 5
Page(s):
571–577
Restricted access
Get Permissions

To study the polyclonal B-lymphocyte stimulation or activation (PBA) phenomenon in human malaria, the numbers of immunoglobulin (G, A, and M)-secreting cells in the peripheral blood, serum levels of immunoglobulins, and the presence of antibodies directed against the DNA-autoantigen were evaluated in Plasmodium falciparum- and P. vivax-infected individuals. Individuals chronically exposed to the risk of infection or non-immune subjects who contracted malaria during first visits to endemic areas were studied. Numbers of immunoglobulin-secreting cells (IgSC) were increased dependent upon ongoing parasitemia. Levels of IgG and the anti-DNA activity were also augmented in malarious individuals from the endemic area. Study of the kinetics of PBA done in treated patients showed that PBA decreased during treatment and disappeared 5–15 days after the start of chemotherapy.
Copyright:
Copyright © 1991 by The American Society of Tropical Medicine and Hygiene 1991
Published Online:
May 1991
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 274 88 8
Full Text Views 20 5 0
PDF Downloads 21 8 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save