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Comparison of Antimalarial Efficacy of α, β, and α/β Arteether against Plasmodium cynomolgi B Infection in Monkeys
Renu Tripathi
Renu Tripathi
Central Drug Research Institute, Central Institute of Medicinal and Aromatic Plants, Lucknow, India
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G. P. Dutta
G. P. Dutta
Central Drug Research Institute, Central Institute of Medicinal and Aromatic Plants, Lucknow, India
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R. A. Vishwakarma
R. A. Vishwakarma
Central Drug Research Institute, Central Institute of Medicinal and Aromatic Plants, Lucknow, India
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The blood schizontocidal activity of α and β arteether has been compared with that of α/β arteether (a 30:70 mixture of α and β isomers), which is a fast-acting blood schizontocide undergoing phase I clinical trials at the Central Drug Research Institute. Both β and α/β arteether have comparable activity and are curative at a dose of 5 mg/kg for 3 days against blood-induced Plasmodium cynomolgi B infection in the rhesus monkey; α arteether alone is slightly less active, with a 50% cure rate at the above dose.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 224 | 92 | 4 |
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| PDF Downloads | 12 | 0 | 0 |