An Immunogenetically Defined and Immunodominant Trypanosoma Cruzi Antigen

Rodrigo Ramos Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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Maria Juri Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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Alicia Ramos Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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Gustavo Hoecker Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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Sergio Lavandero Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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Pedro Pena Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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Antonio Morello Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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Yolanda Repetto Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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Juan Carlos Aguillon Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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Arturo Ferreira Universidad de Chile, Ministerio de Salud, Servicio de Salud Metropolitano Sur, Santiago, Chile

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DOI:
https://doi.org/10.4269/ajtmh.1991.44.314
Volume/Issue:
Volume 44: Issue 3
Page(s):
314–322
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Two strains of mice, A. SW (H-2s) and A.CA (H-2f), were immunized with live trypomastigotes or epimastigotes of the Tulahuen strain of Trypanosoma cruzi or with their sonicates. By immunowestern blotting, sera from A.SW mice, but not from A.CA, recognized, in an immunodominant fashion, a 45 kDal polypeptide (Tc45) present in both epimastigotes and trypomastigotes. Since A.SW and A.CA strains are congenic for the major histocompatibility H-2 complex, recognition of Tc45 seems to be controlled by this genetic region or by gene(s) located in its immediate vicinity. Subcellular fractionation revealed that Tc45 is mainly present at the cytoplasmic compartment.

Author Notes

Copyright:
Copyright © 1991 by The American Society of Tropical Medicine and Hygiene 1991
Published Online:
Mar 1991
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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