Naturally Acquired Circumsporozoite Antibodies and their Role in Protection in Endemic Falciparum and Vivax Malaria

Chansuda Wongsrichanalai United States Army Medical Component, Armed Forces Research Institute of Medical Sciences; Malaria Division, Ministry of Public Health, Bangkok, Thailand

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H. Kyle Webster United States Army Medical Component, Armed Forces Research Institute of Medical Sciences; Malaria Division, Ministry of Public Health, Bangkok, Thailand

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Barnyen Permpanich United States Army Medical Component, Armed Forces Research Institute of Medical Sciences; Malaria Division, Ministry of Public Health, Bangkok, Thailand

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Nipon Chuanak United States Army Medical Component, Armed Forces Research Institute of Medical Sciences; Malaria Division, Ministry of Public Health, Bangkok, Thailand

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Sanchai Ketrangsri United States Army Medical Component, Armed Forces Research Institute of Medical Sciences; Malaria Division, Ministry of Public Health, Bangkok, Thailand

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DOI:
https://doi.org/10.4269/ajtmh.1991.44.201
Volume/Issue:
Volume 44: Issue 2
Page(s):
201–204
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The role of naturally acquired circumsporozoite (CS) antibodies in protection against falciparum and vivax malaria was evaluated in a group of Thai endemic villagers using a prospective cohort and a case-control study design. There was no evidence of protection by either the presence of positive CS antibody levels at the presumed time of sporozoite exposure or in individuals who persistently had measurable levels of the antibodies. The study defined levels of CS antibodies that were not protective in natural infection.

Author Notes

Copyright:
Copyright © 1991 by The American Society of Tropical Medicine and Hygiene 1991
Published Online:
Feb 1991
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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