Experimental Onchocerca Volvulus Infections in Mangabey Monkeys (Cercocebus Atys) Compared to Infections in Humans and Chimpanzees (Pan Troglodytes)

Mark L. Eberhard Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Yerkes Regional Primate Research Center, Emory University, Centro de Investigaciones en Enfermedades Tropicales, Universidad del Valle de Guatemala, Ministry of Health, Atlanta, Georgia

Search for other papers by Mark L. Eberhard in
Current site
Google Scholar
PubMed Close
,
Jennifer W. Dickerson Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Yerkes Regional Primate Research Center, Emory University, Centro de Investigaciones en Enfermedades Tropicales, Universidad del Valle de Guatemala, Ministry of Health, Atlanta, Georgia

Search for other papers by Jennifer W. Dickerson in
Current site
Google Scholar
PubMed Close
,
Anne E. Boyer Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Yerkes Regional Primate Research Center, Emory University, Centro de Investigaciones en Enfermedades Tropicales, Universidad del Valle de Guatemala, Ministry of Health, Atlanta, Georgia

Search for other papers by Anne E. Boyer in
Current site
Google Scholar
PubMed Close
,
Victor C. W. Tsang Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Yerkes Regional Primate Research Center, Emory University, Centro de Investigaciones en Enfermedades Tropicales, Universidad del Valle de Guatemala, Ministry of Health, Atlanta, Georgia

Search for other papers by Victor C. W. Tsang in
Current site
Google Scholar
PubMed Close
,
Rodolpho Zea-Flores Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Yerkes Regional Primate Research Center, Emory University, Centro de Investigaciones en Enfermedades Tropicales, Universidad del Valle de Guatemala, Ministry of Health, Atlanta, Georgia

Search for other papers by Rodolpho Zea-Flores in
Current site
Google Scholar
PubMed Close
,
Essie M. Walker Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Yerkes Regional Primate Research Center, Emory University, Centro de Investigaciones en Enfermedades Tropicales, Universidad del Valle de Guatemala, Ministry of Health, Atlanta, Georgia

Search for other papers by Essie M. Walker in
Current site
Google Scholar
PubMed Close
,
Frank O. Richards Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Yerkes Regional Primate Research Center, Emory University, Centro de Investigaciones en Enfermedades Tropicales, Universidad del Valle de Guatemala, Ministry of Health, Atlanta, Georgia

Search for other papers by Frank O. Richards in
Current site
Google Scholar
PubMed Close
,
Guillermo Zea-Flores Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Yerkes Regional Primate Research Center, Emory University, Centro de Investigaciones en Enfermedades Tropicales, Universidad del Valle de Guatemala, Ministry of Health, Atlanta, Georgia

Search for other papers by Guillermo Zea-Flores in
Current site
Google Scholar
PubMed Close
, and
Elizabeth Strobert Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Yerkes Regional Primate Research Center, Emory University, Centro de Investigaciones en Enfermedades Tropicales, Universidad del Valle de Guatemala, Ministry of Health, Atlanta, Georgia

Search for other papers by Elizabeth Strobert in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1991.44.151
Volume/Issue:
Volume 44: Issue 2
Page(s):
151–160
Restricted access
Get Permissions

Three chimpanzees, three mangabey monkeys (Cercocebus atys), and 14 patas monkeys (Erythrocebus patas) were inoculated with L3 Onchocerca volvulus of Guatemalan origin. One chimpanzee and two mangabey monkeys developed antibody activity to at least three different antigens. Both mangabey monkeys recognized a 20 kDa antigen 3.5–5 months post-inoculation, and the monkeys and the chimpanzee developed antibody activity to 14 and 22 kDa antigens 7.5–13 months post-inoculation. One mangabey monkey and the chimpanzee became microfilaria-positive in skin snips at 16 and 21 months post-inoculation, respectively. Antibody activity to the 20 kDa antigen in the mangabey monkeys is noteworthy because of the prominence of this antigen among putatively immune persons living in onchocerciasis-endemic areas. The two mangabey monkeys responded parasitologically in a manner comparable to immune humans. No microfilariae were detected in one monkey and only scant numbers of microfilariae were observed in the second. The mangabey monkey may be a good animal model for the study of onchocerciasis.

Author Notes

Copyright:
Copyright © 1991 by The American Society of Tropical Medicine and Hygiene 1991
Published Online:
Feb 1991
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 1461 1160 49
Full Text Views 27 4 3
PDF Downloads 34 7 5
 

 

 

 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save