Immunization of Owl Monkeys with the Ring-Infected Erythrocyte Surface Antigen of Plasmodium falciparum

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  • Center for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia
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Aotus nancymai were immunized with the 4-mer, 8-mer, and 11-mer repeat peptides of the ring-infected erythrocyte surface antigen molecule of Plasmodium falciparum conjugated to diphtheria toxoid with muramyl dipeptide (MDP) as adjuvant. Immunization failed to induce protective immunity against the Uganda Palo Alto strain of P. falciparum as judged by maximum levels of parasitemia of immunized monkeys relative to those of controls. The fused polypeptide FPAg632, when combined with MDP, also failed to induce protective immunity. However, the maximum level of parasitemia and serologic response to the 11-mer peptide were inversely correlated. The safety of the use of MDP was evident.