Immunization of Owl Monkeys with the Ring-Infected Erythrocyte Surface Antigen of Plasmodium falciparum

William E. CollinsCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Robin F. AndersCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Trenton K. Ruebush IICenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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David J. KempCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Graeme C. WoodrowCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Gary H. CampbellCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Graham V. BrownCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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David O. IrvingCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Neil GossCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Valerie K. FilipskiCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Ross L. CoppelCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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J. Roger BrodersonCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Lynda M. ThomasCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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David PyeCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Jimmie C. SkinnerCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Carla WilsonCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Peggy S. StanfillCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Patricia M. ProcellCenter for Infectious Diseases, Walter and Elisa Hall Institute for Medical Research, Biotechnology Australia Pty. Ltd., Commonwealth Serum Laboratories, Atlanta, Georgia

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Aotus nancymai were immunized with the 4-mer, 8-mer, and 11-mer repeat peptides of the ring-infected erythrocyte surface antigen molecule of Plasmodium falciparum conjugated to diphtheria toxoid with muramyl dipeptide (MDP) as adjuvant. Immunization failed to induce protective immunity against the Uganda Palo Alto strain of P. falciparum as judged by maximum levels of parasitemia of immunized monkeys relative to those of controls. The fused polypeptide FPAg632, when combined with MDP, also failed to induce protective immunity. However, the maximum level of parasitemia and serologic response to the 11-mer peptide were inversely correlated. The safety of the use of MDP was evident.

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