In Vitro and Ex-Vivo Models of Sequestration in Plasmodium falciparum Infection

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  • Walter Reed Army Institute of Research, Washington, DC

Sequestration is the process by which erythrocytes infected with the mature forms of the malarial parasite Plasmodium falciparum disappear from circulation and accumulate within venules and capillaries of various organs and tissues. Several laboratory models of this phenomena are briefly described with a discussion of their values and shortcomings.