Antibody Response to the 43 kDa Glycoprotein of Paracoccidioides brasiliensis as a Marker for the Evaluation of Patients under Treatment

Maria José Soares Mendes GianniniFaculdade de Ciências Farmacêuticas-UNESP, Faculdade de Medicina-USP, Instituto de Ciências Biomédicas-USP, Instituta de Medicina Tropical de São Paulo, Centro de Biotecnologia do Estado do Rio Grande do Sul, Araraquara, Brazil

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João Paulo BuenoFaculdade de Ciências Farmacêuticas-UNESP, Faculdade de Medicina-USP, Instituto de Ciências Biomédicas-USP, Instituta de Medicina Tropical de São Paulo, Centro de Biotecnologia do Estado do Rio Grande do Sul, Araraquara, Brazil

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Maria Aparecida Shikanai-YasudaFaculdade de Ciências Farmacêuticas-UNESP, Faculdade de Medicina-USP, Instituto de Ciências Biomédicas-USP, Instituta de Medicina Tropical de São Paulo, Centro de Biotecnologia do Estado do Rio Grande do Sul, Araraquara, Brazil

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Ana Maria S. StolfFaculdade de Ciências Farmacêuticas-UNESP, Faculdade de Medicina-USP, Instituto de Ciências Biomédicas-USP, Instituta de Medicina Tropical de São Paulo, Centro de Biotecnologia do Estado do Rio Grande do Sul, Araraquara, Brazil

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Aoi MasudaFaculdade de Ciências Farmacêuticas-UNESP, Faculdade de Medicina-USP, Instituto de Ciências Biomédicas-USP, Instituta de Medicina Tropical de São Paulo, Centro de Biotecnologia do Estado do Rio Grande do Sul, Araraquara, Brazil

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Vicente Amato NetoFaculdade de Ciências Farmacêuticas-UNESP, Faculdade de Medicina-USP, Instituto de Ciências Biomédicas-USP, Instituta de Medicina Tropical de São Paulo, Centro de Biotecnologia do Estado do Rio Grande do Sul, Araraquara, Brazil

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Antonio Walter FerreiraFaculdade de Ciências Farmacêuticas-UNESP, Faculdade de Medicina-USP, Instituto de Ciências Biomédicas-USP, Instituta de Medicina Tropical de São Paulo, Centro de Biotecnologia do Estado do Rio Grande do Sul, Araraquara, Brazil

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Sera of patients with paracoccidioidomycosis contained IgG-, IgA-, and IgM-specific antibodies to a 43 kDa antigen contained in the filtrate of a culture of Paracoccidioides brasiliensis. IgG- and IgA-specific antibodies were present in all observed patients. The IgM response was more frequent in acute cases, and the mean titers of IgG- and IgM-specific antibodies were higher in the acute forms. By the fourth month of chemotherapy, there was a decay of IgG, IgA, and IgM antibody titers to this antigen in acute cases, correlating with clinical improvement. The detection of IgG and IgA antibodies and the sequential determination of antibodies to the 43 kDa glycoprotein may be useful tools for serodiagnosis and evaluation of therapeutic efficacy.

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