Radical Curative Activity of a New 8-Aminoquinoline Derivative (CDRI 80/53) against Plasmodium cynomolgi B in Monkeys

G. P. Dutta Division of Microbiology and Medicinal Chemistry, Central Drug Research Institute, Lucknow, India

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S. K. Puri Division of Microbiology and Medicinal Chemistry, Central Drug Research Institute, Lucknow, India

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A. P. Bhaduri Division of Microbiology and Medicinal Chemistry, Central Drug Research Institute, Lucknow, India

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Manju Seth Division of Microbiology and Medicinal Chemistry, Central Drug Research Institute, Lucknow, India

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An analogue of primaquine, N1-(3-acetyl-4-5-dihydro-2-furanyl)-N4-(6-methoxy-8-quinolinyl) 1, 4-pentanediamine, CDRI Code 80/53), has been evaluated for anti-relapse activity against sporozoite induced Plasmodium cynomolgi B infection in rhesus monkeys. The compound has shown 100% curative anti-relapse activity at 1.25 mg/kg × 7 day dose schedule, thereby giving a primaquine index of 0.8. The compound is currently under Phase-I clinical trials.

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