Monoclonal Antibodies for Dengue Virus prM Glycoprotein Protect Mice against Lethal Dengue Infection

B. M. Kaufman Walter Reed Army Institute of Research, Washington, DC

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P. L. Summers Walter Reed Army Institute of Research, Washington, DC

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D. R. Dubois Walter Reed Army Institute of Research, Washington, DC

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W. Houston Cohen Walter Reed Army Institute of Research, Washington, DC

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M. K. Gentry Walter Reed Army Institute of Research, Washington, DC

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R. L. Timchak Walter Reed Army Institute of Research, Washington, DC

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D. S. Burke Walter Reed Army Institute of Research, Washington, DC

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K. H. Eckels Walter Reed Army Institute of Research, Washington, DC

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DOI:
https://doi.org/10.4269/ajtmh.1989.41.576
Volume/Issue:
Volume 41: Issue 5
Page(s):
576–580
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Five murine monoclonal antibodies (Mabs) reactive against the prM glycoproteins of DEN-3 and -4 were used to passively protect mice in vivo against lethal challenge with homologous and heterologous dengue virus serotypes. Four of the 5 prM-reactive monoclonals cross-protected mice against heterologous challenge, whereas 1 protected against challenge with only the homologous serotype. Although in vitro binding to virions was readily demonstrated, only 2 of the prM Mabs had detectable neutralizing activity. The neutralizing activity could not be enhanced by anti-mouse immunoglobulin or complement. However, 4 of the 5 prM Mabs fixed complement. This is the first report of prM-specific Mabs that are protective in mice.
Copyright:
Copyright © 1989, by The American Society of Tropical Medicine and Hygiene 1989
Published Online:
Nov 1989
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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