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Diversity of Antigens Expressed on the Surface of Erythrocytes Infected with Mature Plasmodium Falciparum Parasites in Papua New Guinea
Karen P. Forsyth
Karen P. Forsyth
Papua New Guinea Institute of Medical Research, Walter and Eliza Hall Institute of Medical Research, Madang, Papua New Guinea
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Gideon Philip
Gideon Philip
Papua New Guinea Institute of Medical Research, Walter and Eliza Hall Institute of Medical Research, Madang, Papua New Guinea
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Trudy Smith
Trudy Smith
Papua New Guinea Institute of Medical Research, Walter and Eliza Hall Institute of Medical Research, Madang, Papua New Guinea
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Eric Kum
Eric Kum
Papua New Guinea Institute of Medical Research, Walter and Eliza Hall Institute of Medical Research, Madang, Papua New Guinea
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Bridget Southwell
Bridget Southwell
Papua New Guinea Institute of Medical Research, Walter and Eliza Hall Institute of Medical Research, Madang, Papua New Guinea
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Graham V. Brown
Graham V. Brown
Papua New Guinea Institute of Medical Research, Walter and Eliza Hall Institute of Medical Research, Madang, Papua New Guinea
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Antigens were detected on the surface of erythrocytes from children with acute falciparum malaria in Madang, Papua New Guinea. These parasite-induced erythrocyte surface antigens (PIESA) were serotyped with convalescent sera from children and hyperimmune sera from adults in parasite infected cell agglutination assays (PICAs) and by inhibition of binding of infected cells to melanoma cells. Extensive serological diversity of PIESA was demonstrated. A significant correlation between serotypes defined by reactivity of immune sera in PICA and inhibition of melanoma cell binding (MCB) was observed. This suggests that both assays measure antibody responses to the same antigen(s). Increased recognition of different PIESA specificities with age is consistent with the hypothesis that repeated exposure to malaria confers immunity against a range of PIESA serotypes and parallels the development of clinical immunity to malaria in this area of Papua New Guinea.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 290 | 101 | 6 |
| Full Text Views | 6 | 0 | 0 |
| PDF Downloads | 2 | 0 | 0 |