Eosinophil Hyporesponse of Jirds Induced by Microfilariae of Brugia Pahangi

Yoichiro HoriiNagasaki University School of Medicine, School of Allied Medical Sciences, Nagasaki University, Tokyo Medical and Dental University, Nagasaki, Japan

Search for other papers by Yoichiro Horii in
Current site
Google Scholar
PubMed
Close
,
Hirokuni NakanishiNagasaki University School of Medicine, School of Allied Medical Sciences, Nagasaki University, Tokyo Medical and Dental University, Nagasaki, Japan

Search for other papers by Hirokuni Nakanishi in
Current site
Google Scholar
PubMed
Close
,
Akio MoriNagasaki University School of Medicine, School of Allied Medical Sciences, Nagasaki University, Tokyo Medical and Dental University, Nagasaki, Japan

Search for other papers by Akio Mori in
Current site
Google Scholar
PubMed
Close
,
Makoto ZaitsuNagasaki University School of Medicine, School of Allied Medical Sciences, Nagasaki University, Tokyo Medical and Dental University, Nagasaki, Japan

Search for other papers by Makoto Zaitsu in
Current site
Google Scholar
PubMed
Close
,
Masakatsu UedaNagasaki University School of Medicine, School of Allied Medical Sciences, Nagasaki University, Tokyo Medical and Dental University, Nagasaki, Japan

Search for other papers by Masakatsu Ueda in
Current site
Google Scholar
PubMed
Close
,
Kenji KurokawaNagasaki University School of Medicine, School of Allied Medical Sciences, Nagasaki University, Tokyo Medical and Dental University, Nagasaki, Japan

Search for other papers by Kenji Kurokawa in
Current site
Google Scholar
PubMed
Close
,
Tsutomu OdaNagasaki University School of Medicine, School of Allied Medical Sciences, Nagasaki University, Tokyo Medical and Dental University, Nagasaki, Japan

Search for other papers by Tsutomu Oda in
Current site
Google Scholar
PubMed
Close
, and
Koichiro FujitaNagasaki University School of Medicine, School of Allied Medical Sciences, Nagasaki University, Tokyo Medical and Dental University, Nagasaki, Japan

Search for other papers by Koichiro Fujita in
Current site
Google Scholar
PubMed
Close
Restricted access

Male jirds (Meriones unguiculatus) were inoculated sc with 100 infective larvae of Brugia pahangi. After 16 weeks, the animals were reinoculated with a comparable number of organisms. Blood eosinophil responses during the 5 weeks subsequent to this attempt to reinfect were much lower than those of comparable naive animals, while the response to a heterologous infection (Toxocara canis) was comparable to that of controls. Mebendazole was given to infected animals for 2 weeks beginning 5 weeks (prepatent) or 16 weeks (patent) after infection. At comparable intervals after drug administration, the animals were reinoculated with infective larvae and the blood eosinophil response was measured over a 5 week period. The response in the animals treated during the prepatent period was higher than the untreated infected controls. Treatment during the patent period had no demonstrable effect. Jirds made artificially microfilaremic by intravenous inoculation of viable filaria before and after the standard infecting dose had a low eosinophil response to infective larvae.

A primary experience of jirds with the microfilariae of B. pahangi evokes an eosinophil response. Subsequent inoculation of larvae did not produce a comparable response.

Save