Identification of Taenia Solium Antigens in Cerebrospinal Fluid and Larval Antigens from Patients with Neurocysticercosis

John J. Estrada Universidad de Antioquia, Wake Forest University, AA 1226 Medellin, Colombia

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Jane Almon Estrada Universidad de Antioquia, Wake Forest University, AA 1226 Medellin, Colombia

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Raymond E. Kuhn Universidad de Antioquia, Wake Forest University, AA 1226 Medellin, Colombia

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DOI:
https://doi.org/10.4269/ajtmh.1989.41.50
Volume/Issue:
Volume 41: Issue 1
Page(s):
50–55
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Two antigens (190 and 230 kDa) of the larvae of Taenia solium were detected in the cerebrospinal fluid (CSF) of 14 of 18 patients in which neurocysticercosis was suspected. Nine of these were confirmed by histopathology. Seven antigens were detected in cyst fluid of T. solium larvae removed from the brains of 6 infected patients. Two of these antigens had the same M, as the T. solium antigens detected in the CSF. Polyacrylamide gel electrophoresis and electro-immunoblotting analyses were used for the identification and characterization. Antibodies in rabbit anti-larval antiserum and antibodies in sera of infected individuals recognized the same larval antigens in the larval cyst fluids and in the CSF of infected patients.
Copyright:
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene 1989
Published Online:
Jul 1989
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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