Experimental Murine Chromomycosis Mimicking Chronic Progressive Human Disease

Joan AhrensAudie L. Murphy Memorial Veterans' Hospital, University of Texas Health Science Center at San Antonio, San Antonio Texas

Search for other papers by Joan Ahrens in
Current site
Google Scholar
PubMed
Close
,
John R. GraybillAudie L. Murphy Memorial Veterans' Hospital, University of Texas Health Science Center at San Antonio, San Antonio Texas

Search for other papers by John R. Graybill in
Current site
Google Scholar
PubMed
Close
,
Aida AbishawlAudie L. Murphy Memorial Veterans' Hospital, University of Texas Health Science Center at San Antonio, San Antonio Texas

Search for other papers by Aida Abishawl in
Current site
Google Scholar
PubMed
Close
,
Fermin O. TioAudie L. Murphy Memorial Veterans' Hospital, University of Texas Health Science Center at San Antonio, San Antonio Texas

Search for other papers by Fermin O. Tio in
Current site
Google Scholar
PubMed
Close
, and
Michael G. RinaldiAudie L. Murphy Memorial Veterans' Hospital, University of Texas Health Science Center at San Antonio, San Antonio Texas

Search for other papers by Michael G. Rinaldi in
Current site
Google Scholar
PubMed
Close
Restricted access

Congenitally athymic (nu/nu) mice, mice defective in NK cell and macrophage function (bg/bg), and normal BALB/c mice were inoculated sc with 105–6 conidia of Fonsecaea pedrosoi (FP). In immunologically intact and immunodeficient mice, a local infection developed approximately 2 weeks post-inoculation and enlarged over 1–2 weeks. In bg/bg and normal nu/+ mice, lesions resolved within 5–6 weeks. However, nu/nu mice continued to have enlarging sc lesions during >4–6 months of observation. These eventually metastasized. Lesions contained few hyphal elements and massive numbers of sclerotic bodies. Five weeks after inoculation, 104–6 conidia forming units/gm of tissue were recovered from lesions. Delayed type hypersensitivity and serum antibody to FP antigens were demonstrated. Adoptive transfer of lymphocytes from nu/+ mice was followed in 2 months by the resolution of the lesions.

Save