Cross-Reacting Antigens to Pc96, a Protective Antigen of Plasmodium chabaudi, in P. falciparum, P. vivax, and P. cynomolgi

Chingchai WanidworanunNew York University Medical Center, Institute of Pathology, Case Western Reserve University, New York, New York

Search for other papers by Chingchai Wanidworanun in
Current site
Google Scholar
PubMed
Close
,
John W. BarnwellNew York University Medical Center, Institute of Pathology, Case Western Reserve University, New York, New York

Search for other papers by John W. Barnwell in
Current site
Google Scholar
PubMed
Close
,
Hideyuki NagasawaNew York University Medical Center, Institute of Pathology, Case Western Reserve University, New York, New York

Search for other papers by Hideyuki Nagasawa in
Current site
Google Scholar
PubMed
Close
,
Masamichi AikawaNew York University Medical Center, Institute of Pathology, Case Western Reserve University, New York, New York

Search for other papers by Masamichi Aikawa in
Current site
Google Scholar
PubMed
Close
, and
Hannah L. ShearNew York University Medical Center, Institute of Pathology, Case Western Reserve University, New York, New York

Search for other papers by Hannah L. Shear in
Current site
Google Scholar
PubMed
Close
Restricted access

Mice can be partially protected against Plasmodium chabaudi by immunization with the antigen Pc96, isolated from the erythrocyte membranes of infected mice. We used a Pc96 specific monoclonal antibody to identify antigens which cross-react with Pc96 in P. falciparum, P. vivax, and P. cynomolgi. The cross-reactive molecules are antigens of Mr 155,000 in P. falciparum, Mr 220,000 in P. vivax, and Mr 200,000 in P. cynomolgi. They are located in the surface membranes of infected erythrocytes. Pc96 is characterized by immunoelectron microscopy and epitope mapping.

Save