It is a great honor to be asked to present the Charles Franklin Craig Lecture of this Society. I initially accepted this responsibility with some trepidation, and after reviewing the list of previous Craig Lecturers, I became even more nervous about the prospects of addressing you. It is indeed an honor to be added to that list.
I would like to express my sincere thanks to those responsible for my selection as the Craig lecturer, including the committee who selected me for this honor, the many collaborators who over the years have made my work much better than it would have otherwise been, and last, but not least, my wife Bobbie whose understanding and tireless support made it all possible.
Charles Franklin Craig helped establish the viral etiology of dengue fever in 1907, so it is appropriate that I talk about this disease today.