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Expression of the Precursor of the Major Merozoite Surface Antigens During the Hepatic Stage of Malaria
Andreas Suhrbier
Andreas Suhrbier
Department of Pure and Applied Biology, Imperial College, Division of Parasitology, National Institute of Medical Research, Department of Tropical Medicine and Parasitology, Tulane Medical Center, London
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Anthony A. Holder
Anthony A. Holder
Department of Pure and Applied Biology, Imperial College, Division of Parasitology, National Institute of Medical Research, Department of Tropical Medicine and Parasitology, Tulane Medical Center, London
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Mark F. Wiser
Mark F. Wiser
Department of Pure and Applied Biology, Imperial College, Division of Parasitology, National Institute of Medical Research, Department of Tropical Medicine and Parasitology, Tulane Medical Center, London
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Jill Nicholas
Jill Nicholas
Department of Pure and Applied Biology, Imperial College, Division of Parasitology, National Institute of Medical Research, Department of Tropical Medicine and Parasitology, Tulane Medical Center, London
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Robert E. Sinden
Robert E. Sinden
Department of Pure and Applied Biology, Imperial College, Division of Parasitology, National Institute of Medical Research, Department of Tropical Medicine and Parasitology, Tulane Medical Center, London
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The precursor of major merozoite surface antigens (PMMSA) and its proteolytic products are candidates for an asexual blood stage vaccine. Previous authors have shown that PMMSA epitopes are expressed in the liver or exoerythrocytic (EE) stage of malaria. Using Plasmodium berghei, we show that the molecular weight of the liver stage PMMSA is similar to that of the blood stage and that both EE and blood stage proteins are similarly processed. In the EE stage, it was synthesized toward the end of schizogony and appeared first to localize to the rough endoplasmic reticulum and then, as the cytomeres began to form, to the parasite plasmalemma. The EE and blood stage merozoites expressed similar amounts of this antigen as determined by indirect immunofluorescence.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 474 | 160 | 20 |
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| PDF Downloads | 2 | 2 | 0 |