Small Area Variation in Prevalence of an S-Antigen Serotype of Plasmodium falciparum in Villages of Madang, Papua New Guinea

Karen P. Forsyth Papua New Guinea Institute of Medical Research, The Walter and Eliza Hall Institute of Medical Research, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

Search for other papers by Karen P. Forsyth in
Current site
Google Scholar
PubMed Close
,
Robin F. Anders Papua New Guinea Institute of Medical Research, The Walter and Eliza Hall Institute of Medical Research, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

Search for other papers by Robin F. Anders in
Current site
Google Scholar
PubMed Close
,
Jacqueline A. Cattani Papua New Guinea Institute of Medical Research, The Walter and Eliza Hall Institute of Medical Research, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

Search for other papers by Jacqueline A. Cattani in
Current site
Google Scholar
PubMed Close
, and
Michael P. Alpers Papua New Guinea Institute of Medical Research, The Walter and Eliza Hall Institute of Medical Research, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

Search for other papers by Michael P. Alpers in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1989.40.344
Volume/Issue:
Volume 40: Issue 4
Page(s):
344–350
Restricted access
Get Permissions

Cross-sectional and longitudinal village-based studies of the transmission dynamics of an S-antigen serotype of the asexual erythrocyte stages of Plasmodium falciparum have been carried out in Madang, Papua New Guinea (PNG). Sera collected from village residents were screened for circulating S-antigen of the FC27 serotype by enzymelinked immunosorbent assay (ELISA). The prevalence of the FC27 S-antigen was found to vary between villages at a given point in time, as well as within a village over time. Residents of villages 2–5 km apart were infected with P. falciparum of different S-antigen serotypes. This study documents the periodic nature of transmission of a sub-population of P. falciparum defined by the FC27 S-antigen. The variation in a small area in the prevalence of this serotype of P. falciparum in Madang illustrates the complexities of malaria transmission which must be considered in the design of malaria vaccine trials.
Copyright:
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene 1989
Published Online:
Apr 1989
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 250 98 4
Full Text Views 6 0 0
PDF Downloads 4 0 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save