Stage Specific Actions of Antimalarial Drugs on Plasmodium falciparum in Culture

Timothy G. Geary Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan

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Alan A. Divo Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan

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James B. Jensen Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan

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DOI:
https://doi.org/10.4269/ajtmh.1989.40.240
Volume/Issue:
Volume 40: Issue 3
Page(s):
240–244
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Chemicals with antimalarial effects show different patterns against ring stages, trophozoites, and schizonts of Plasmodium falciparum in culture. Amodiaquine, mefloquine, quinine, quinacrine, primaquine, qinghaosu, halofantrine, rifampin, antimycin A1, cycloheximide, and actinomycin D were preferentially toxic to the mature stages. Ammonium chloride killed ring stages faster than mature forms, while tetracycline, clindamycin, and halofuginone acted with equal speed on all 3 stages.
Copyright:
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene 1989
Published Online:
Mar 1989
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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