Suppression of Cell-Mediated Immune Responses to Malaria Antigens in Pregnant Gambian Women

E. M. Riley Medical Research Council Laboratories, WEC Clinic, Fajara, Gambia

Search for other papers by E. M. Riley in
Current site
Google Scholar
PubMed Close
,
G. Schneider Medical Research Council Laboratories, WEC Clinic, Fajara, Gambia

Search for other papers by G. Schneider in
Current site
Google Scholar
PubMed Close
,
I. Sambou Medical Research Council Laboratories, WEC Clinic, Fajara, Gambia

Search for other papers by I. Sambou in
Current site
Google Scholar
PubMed Close
, and
B. M. Greenwood Medical Research Council Laboratories, WEC Clinic, Fajara, Gambia

Search for other papers by B. M. Greenwood in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1989.40.141
Volume/Issue:
Volume 40: Issue 2
Page(s):
141ā€“144
Restricted access
Get Permissions

In malaria endemic areas, pregnancy predisposes previously immune women to clinical and subclinical malaria infection. While parameters of humoral immunity do not seem to be affected to pregnancy, suppression of cellular immunity has been demonstrated for a number of antigens. In this study of women from a rural area of the Gambia where falciparum malaria is holoendemic, we show that lymphoproliferative responses to Plasmodium falciparum antigens are depressed in pregnant women compared to parity matched non-pregnant women, and that this effect is particularly marked in primigravidae. The data also indicate that malaria antigen induced Ī³-interferon production may be depressed in pregnant women. There was no significant difference in antimalarial antibody titers between the 2 groups.
Copyright:
Copyright Ā© 1989 by The American Society of Tropical Medicine and Hygiene 1989
Published Online:
Feb 1989
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 321 128 7
Full Text Views 8 0 0
PDF Downloads 6 0 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save