Estimate of Plasmodium Falciparum Sporozoite Content of Anopheles Stephensi used to Challenge Human Volunteers

Jonathan R. Davis Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Department of Medical and Molecular Parasitology, New York University Medical Center, Baltimore, Maryland

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James R. Murphy Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Department of Medical and Molecular Parasitology, New York University Medical Center, Baltimore, Maryland

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David F. Clyde Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Department of Medical and Molecular Parasitology, New York University Medical Center, Baltimore, Maryland

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Shahida Baqar Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Department of Medical and Molecular Parasitology, New York University Medical Center, Baltimore, Maryland

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Alan H. Cochrane Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Department of Medical and Molecular Parasitology, New York University Medical Center, Baltimore, Maryland

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Fidel Zavala Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Department of Medical and Molecular Parasitology, New York University Medical Center, Baltimore, Maryland

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Ruth S. Nussenzweig Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Department of Medical and Molecular Parasitology, New York University Medical Center, Baltimore, Maryland

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DOI:
https://doi.org/10.4269/ajtmh.1989.40.128
Volume/Issue:
Volume 40: Issue 2
Page(s):
128–130
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Plasmodium falciparum infected Anopheles stephensi, taken from a group of mosquitoes which had been used to challenge recipients of (NANP)3-TT vaccine, were tested for P. falciparum sporozoite content by an immunoradiometric assay. Seventy-six percent were infected with mean and median sporozoite equivalents per mosquito of 220,994 and 217,398, respectively (SD = 54,911). This sporozoite density is greater than that usually found in the field. These data suggest that this challenge for evaluating P. falciparum sporozoite vaccines is a demanding test of immunity.

Author Notes

Copyright:
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene 1989
Published Online:
Feb 1989
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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