By H. J. Bensted, W. Bulloch, L. Dudgeon, A. G. Gardner, E. D. W. Greig, D. Harvey, W. F. Harvey, T. J. Mackie, R. A. O'Brien, H. M. Perry, H. Scutze, P. Bruce White, W. J. Wilson. London, 1929. His Majesty's Stationery Office. Pp. 1–482
by A. Trevor Willis, M.D., B.S. (Melb.), Ph.D. (Leeds), M.C.Path., M.C.P.A., Reader in Microbiology, Monash University, formerly Lecturer in Bacteriology, University of Leeds. xiv + 234 pages, illustrated, second edition. Butterworth Inc., Washington. 1965. $8.50
(1)A total of 207 adult males, infected with Schistosoma haematobium but livingin a schistosome-free area, were treated with intramuscular injections of stibophen; 114 of these could be studied post-treatment for six months.
(2)Five different treatment schedules were tested with total drug dosages ranging from 21 cc. to 40 cc., and administered over periods of three to twenty days.
(3)Untoward reactions included anorexia, nausea, vomiting and a skin rash. Some patients also complained of weakness and generalized body pain. The severity and frequency of untoward reactions was positively correlated with the size and frequency of the individual doses, but not necessarily with total drug dosage.
(4)Cure rates, based on the clearance of all schistosome eggs from the urine by the sixth month post-treatment, ranged from 50 to 79 per cent. With adequate total dosage, the more intensive treatment regimes gave the higher cure rates.
(5)Concentrated treatment was followed by earlier relapse as shown by the re-appearance of living eggs, but degenerate eggs may also indicate unsuccessful treatment after an extended course with low dosages.