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Pyrimethamine (Daraprim) in doses of 25 mg. per adult, was administered weekly to 110 individuals living in a small malarial endemic village in Jordan. One hundred and twenty other individuals living in the same village who served as the control group received placebos. During the 18-week period of the study (June 20 to October 24, 1954), 25 of the control group developed malaria (P. vivax) whereas no cases of malaria occurred among the pyrimethamine treated individuals.
Senior Scientist (R), Division of International Health, U. S. Public Health Service; Parasitologist, University of Hawaii.
Assistant Parasitologist, Central Government Laboratory, Amman, Jordan.