Identity of Karelian Fever and Ockelbo Viruses Determined by Serum Dilution-Plaque Reduction Neutralization Tests and Oligonucleotide Mapping

Dmitri K. Lvov
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Elena A. Vladimirtseva
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Alexander M. Butenko
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N. Karabatsos D. I. Ivanovsky Institute of Virology, USSR Academy of Medical Sciences, 123098 Moscow, USSR

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Dennis W. Trent Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado 80522

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Charles H. Calisher Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado 80522

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DOI:
https://doi.org/10.4269/ajtmh.1988.39.607
Volume/Issue:
Volume 39: Issue 6
Page(s):
607–610
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The causative agents of Ockelbo disease in Sweden, Pogosta disease in Finland, and Karelian fever in the USSR have been attributed to alphaviruses (family Togaviriade) related to Sindbis virus. We compared prototypes Sindbis, Ockelbo, and Karelian fever viruses by neutralization tests. We also analyzed oligonucleotide fingerprint maps of prototypes Ockelbo and Karelian fever viruses and a strain of Sindbis virus from Czechoslovakia. The results indicate that Ockelbo and Karelian fever viruses are essentially identical and suggest that Ockelbo disease, Pogosta disease, and Karelian fever are synonyms for the same disease.

Author Notes

Copyright:
Copyright 1988 © by The Animal Society of Tropical Medicine and Hygiene 1988
Accepted:
05 Jul 1988
|
Published Online:
Dec 1988
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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