Isolation of a Newly Recognized Bunyamwera Serogroup Virus from a Febrile Human in Panama

J. A. Mangiafico Disease Assessment Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701

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J. L. Sanchez Preventive Service, United States Army Medical Department Activity, Fort Bragg, North Carolina 28307

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L. T. Figueiredo Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine New Haven, Connecticut 06510

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J. W. LeDuc Disease Assessment Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701

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C. J. Peters Disease Assessment Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701

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A virus, strain 86MSP18, was isolated from the acute phase serum of a U.S. soldier with a febrile illness. He was stationed at Fort Sherman in the Republic of Panama when the onset of his illness occurred. A rise in neutralizing antibody to the viral isolate was observed between the patient's acute and convalescent-phase serum samples. Virus strain 86MSP18 has been shown by plaque reduction neutralization to be closely related to but distinct from Cache Valley virus and known subtypes. It appears to be a newly recognized subtype of Cache Valley virus and is believed to be the second isolation of a Cache Valley virus subtype from a human with a febrile illness. The name “Fort Sherman” virus for strain 86MSP18 is proposed.

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