Interaction of Malaysian Sera with Plasmodium Vivax Sporozoite Antigen

Melinda Lee
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Don R. Davis
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W. Ripley Ballou Department of Immunology, Walter Reed Army Institute of Research, Washington, DC 20307

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Gail Folena-Wasserman Department of Protein Biochemistry, SK&F Laboratories, Swedeland, Pennsylvania

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George E. Lewis
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DOI:
https://doi.org/10.4269/ajtmh.1988.39.535
Volume/Issue:
Volume 39: Issue 6
Page(s):
535–539
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A seroepidemiologic survey of Plasmodium vivax and Plasmodium falciparum transmission was conducted in 94 Orang Asli children and adults. The prevalence of malaria was 46% in this population, and infections due to P. vivax and P. falciparum occurred with equal frequency. Multi-species infection was common, particularly in children <10 years of age. Circumsporozoite (CS) antibodies to P. vivax were detected by ELISA, using the recombinant protein NS181 V20, in sera from 53–95% of all subjects in this study. The specificity of reactivity to NS181 V20 was confirmed by immunofluorescence using air-dried sporozoites. CS antibodies to P. falciparum were present in <50% of the population <30 years of age. These data support further testing of this protein as a candidate vivax vaccine.

Author Notes

Copyright:
Copyright 1988 © by The Animal Society of Tropical Medicine and Hygiene 1988
Accepted:
29 May 1988
|
Published Online:
Dec 1988
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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