Cultivation of Exoerythrocytic Stages of Plasmodium Cynomolgi, P. Knowlesi, P. Coatneyi, and P. Inui in Macaca Mulatta Hepatocytes

Pascal Millet
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Tamara L. Fisk
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William E. Collins
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J. Roger Broderson Malaria Branch, Division of Parasitic Diseases

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Phuc Nguyen-Dinh
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DOI:
https://doi.org/10.4269/ajtmh.1988.39.529
Volume/Issue:
Volume 39: Issue 6
Page(s):
529–534
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Exoerythrocytic stage parasites of Plasmodium cynomolgi, P. knowlesi, P. coatneyi, and P. inui were cultured by inoculating primary cultures of hepatocytes from Macaca mulatta with sporozoites. Less than 1% of inoculated sporozoites survived. Morphology and size of the liver stages in all 4 species were similar to in vivo descriptions and the time required for in vitro maturation correlated well with prepatent periods described.

Author Notes

Copyright:
Copyright 1988 © by The Animal Society of Tropical Medicine and Hygiene 1988
Accepted:
03 Jul 1988
|
Published Online:
Dec 1988
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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