Failure of a Dengue 1 Sub-Unit Vaccine to Protect Mice against a Lethal Dengue Virus Infection

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  • * Department of Medical Laboratory Science, Queensland Institute of Technology, Brisbane
  • | Queensland Institute of Medical Research, Brisbane, Australia

Mice immunized with DEN-1 pre-matrix protein produced antibody which reacted with dengue virus infected cells and intact virions but failed to neutralize virus in vitro or in vivo. Newborn mice passively immunized with anti-DEN-1 pre-matrix antibody also failed to survive intracerebral infection with 100 LD50 of any dengue virus serotype.

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