The Synergistic Action of Pyrazolopyrimidines and Pentavalent Antimony against Leishmania donovani and L. braziliensis

Samuel Martinez Department of Medicine, University of Cauca, Division of Infectious Diseases, University of Colorado Health Sciences Center, Popoyan, Colombia

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Douglas L. Looker
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Randolph L. Berens
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J. Joseph Marr
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DOI:
https://doi.org/10.4269/ajtmh.1988.39.250
Volume/Issue:
Volume 39: Issue 3
Page(s):
250–255
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Pyrazolopyrimidines, particularly allopurinol, allopurinol riboside, and other purine analogues, show promise as experimental therapeutic compounds for the treatment of leishmaniasis. The combination of these agents with pentostam may produce an improved therapeutic effect. We report here on strong synergistic activity between pyrazolopyrimidines and pentavalent antimonials in a human macrophage tissue culture system infected with Leishmania donovani and L. braziliensis.
Copyright:
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene 1988
Accepted:
08 Mar 1988
|
Published Online:
Sep 1988
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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