Antibody Responses to Malarial Antigens in the Wopkaimin Population of the Star Mountains, Papua New Guinea

William E. Collins Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia

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Jacqueline Cattani Departments of Human Biology and Community Medicine, University of Papua New Guinea

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John A. Lourie Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

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Tukutau Taufa Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

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William Anderson Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

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Jimmie C. Skinner Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia

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Peggy S. Stanfill Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia

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Alan Y. Huong Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia

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DOI:
https://doi.org/10.4269/ajtmh.1988.39.241
Volume/Issue:
Volume 39: Issue 3
Page(s):
241–245
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Antibody responses to malarial antigens were determined in 614 serum samples collected from the Wopkaimin population of the Star Mountains of Papua New Guinea. In point prevalence surveys made in 1982–1983, 33.7% of the persons examined were infected with Plasmodium falciparum, P. vivax, or P. malariae. Of these, 72.9% were infected with P. falciparum. In a standard fluorescent antibody test, highest level responses were to P. falciparum, followed by P. malariae, P. vivax, and P. ovale. A strong correlation was found between results of the fluorescent antibody tests and those obtained in an enzymelinked immunosorbent assay using P. falciparum antigens. The failure of immune responses to eliminate these species of Plasmodium in this highly isolated population is discussed.

Author Notes

Copyright:
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene 1988
Accepted:
24 Mar 1988
|
Published Online:
Sep 1988
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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