Hyperreactive Malarial Splenomegaly in Venezuela

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  • 1 Institute de Medicina Tropical, Universidad Central de Venezuela, Caracas, Venezuela
  • | * Centro Amazonica para la Investigación en Enfermedades Tropicales, Puerto Ayacucho, TFA, Venezuela
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A cross-sectional seroepidemiological survey seeking hyperreactive malarial splenomegaly was carried out in isolated Yanomami hamlets in Amazonas Territory in Venezuela. All 110 inhabitants > 1 year of age were evaluated clinically and 98 were studied immunologically.

The spleen index for individuals > 10 years of age was 44%. Only 3 patients had Plasmodium spp. on thick blood smears. All had serological evidence of infection with Plasmodium falciparum and P. vivax. Twenty-three patients were considered to show hyperreactive malarial splenomegaly.

Clinical manifestations of the syndrome did not differ from those described in other parts of the world.