The Effect of Diethylcarbamazine Citrate on Incidence and Recovery Rates of Brugia Malayi Microfilaremia in Sabah, Malaysia

Jeffrey Lu King HiiDepartment of Medical Services, 88814 Kota Kinabalu, Sabah, Malaysia

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Spencer Kin Ping KanDepartment of Medical Services, 88814 Kota Kinabalu, Sabah, Malaysia

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Sidhu Singh ParmarDepartment of Medical Services, 88814 Kota Kinabalu, Sabah, Malaysia

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Mechiel Kin Chung ChanDepartment of Medical Services, 88814 Kota Kinabalu, Sabah, Malaysia

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Joon Wah MakInstitute for Medical Research, Jalan Pahang, 50468 Kuala Lumpur, Malaysia

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Patricia Kim Chool LimInstitute for Medical Research, Jalan Pahang, 50468 Kuala Lumpur, Malaysia

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Teong Wah LimInstitute for Medical Research, Jalan Pahang, 50468 Kuala Lumpur, Malaysia

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David T. DennisState Department of Health and Welfare, New Hampshire 03301

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Mass drug administration via 3 modes of delivery reduced the incidence and prevalence rates and intensity of Brugia malayi infection in 3 rural villages in the Bengkoka Peninsula, Sabah, in 1982–1983. A dosage of 6 mg diethylcarbamazine citrate (DEC-C)/kg body weight was administered either daily or weekly (total of 6 doses, 36 mg/kg body weight), and impact on B. malayi cases were comparable in the 3 villages. A total of 384 people participated in the DEC-C regimens, and all pregnant women and children under 2 years were excluded from the study. Bekessy's method of estimation of incidence and recovery rates was applied to data on B. malayi microfilaremia before drug administration. Treatment with DEC-C by any of the 3 modes of delivery drastically reduced the number of episodes of patent microfilaremia, incidence and prevalence, and median microfilarial density. Reduction was sustained for at least 18 to 24 months after treatment.

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