Efficacy of Metrifonate in a Highly Endemic Area of Urinary Schistosomiasis in Kenya

Katsuyuki SatoDepartment of Parasitology, Institute of Tropical Medicine, Nagasaki University, Japan

Search for other papers by Katsuyuki Sato in
Current site
Google Scholar
PubMed
Close
,
Masaaki ShimadaDepartment of Parasitology, Institute of Tropical Medicine, Nagasaki University, Japan

Search for other papers by Masaaki Shimada in
Current site
Google Scholar
PubMed
Close
,
Shinichi NodaDepartment of Medical Zoology, Faculty of Medicine, Kagoshima University, Japan

Search for other papers by Shinichi Noda in
Current site
Google Scholar
PubMed
Close
,
Ngethe D. MuhohoCentre for Microbiology Research, Kenya Medical Research Institute, Ministry of Health, Kenya

Search for other papers by Ngethe D. Muhoho in
Current site
Google Scholar
PubMed
Close
,
Tatsuya KatsumataDepartment of Parasitology, Institute of Tropical Medicine, Nagasaki University, Japan

Search for other papers by Tatsuya Katsumata in
Current site
Google Scholar
PubMed
Close
,
Atsuo SatoDepartment of Medical Zoology, Faculty of Medicine, Kagoshima University, Japan

Search for other papers by Atsuo Sato in
Current site
Google Scholar
PubMed
Close
, and
Yoshiki AokiDepartment of Parasitology, Institute of Tropical Medicine, Nagasaki University, Japan

Search for other papers by Yoshiki Aoki in
Current site
Google Scholar
PubMed
Close
Restricted access

In a community in Kwale district, Kenya, selective mass chemotherapy with metrifonate caused a marked reduction in the intensity of Schistosoma haematobium infection from 46.5 to 9.4 eggs/hr and a sharp fall in prevalence of gross hematuria from 18.3% to 5.1%, although overall prevalence was reduced only slightly from 67.4% to 54%. The effect of metrifonate on cure rate and reduction of infection intensity was limited by both age and pretreatment infection intensity. Rate of improvement from gross hematuria was similar in all ages and in all classes of intensity of infection. Two doses of metrifonate reduced the prevalence of gross hematuria as much as 3 doses did, while the effect of a single dose on morbidity remains to be clarified.

Save