Morphological Effects of Pyronaridine on Malarial Parasites

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  • 1 Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106
  • | * Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, WHO Collaborating Centre of Malaria, Schistosomiasis and Filariasis, Shanghai 20025, China
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The ultrastructural changes caused by a new antimalarial drug, pyronaridine, were investigated using mice infected with erythrocytic forms of Plasmodium berghei and P. falciparum cultivated in vitro in human erythrocytes. The first changes observed in both parasites after exposure to pyronaridine occurred in the food vacuoles. This suggests that the target organelle of this drug may be the food vacuole of malarial parasites. In addition, rapid alterations were also noted within the pellicular complex of both plasmodia.