Analysis of Dose-Response Curves for the In Vitro Susceptibility of Plasmodium Falciparum to Antimalarials using a Pocket Computer

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  • U.S. Army Medical Component, Armed Forces Research Institute of the Medical Sciences, Rajvithi Road, Bangkok, Thailand
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A small pocket computer, Sharp PC-1500, was programmed to analyze the dose-response curves generated by the in vitro assay of antimalarials against field isolates of Plasmodium falciparum. Using nonlinear regression the analysis provided an estimate of the 50% inhibitory concentration with 95% confidence limits and a graph of the data points and regression function line. The pocket computer with the nonlinear regression program offers a powerful, portable, and inexpensive data analysis system suitable for field use.