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Polyamine Metabolism as a Target for Growth Inhibition of Acanthamoeba culbertsoni
Sanjiv Gupta
Sanjiv Gupta
Division of Biochemistry, Central Drug Research Institute, Lucknow 226 001, India
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Poornima Kishore
Poornima Kishore
Division of Biochemistry, Central Drug Research Institute, Lucknow 226 001, India
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Onkar Prakash Shukla
Onkar Prakash Shukla
Division of Biochemistry, Central Drug Research Institute, Lucknow 226 001, India
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α-difluoromethylornithine had no inhibitory effect on the growth of Acanthamoeba culbertsoni, while methylglyoxal bis(guanyl-hydrazone) and sinefungin completely blocked amebic growth at 2.5 mM and 5 µg/ml concentrations, respectively. Cyclohexylamine caused only partial inhibition of amebic growth at 50–200 µM concentrations. Methylglyoxal bis(guanyl-hydrazone) inhibited S-adenosylmethionine decarboxylase of A. culbertsoni indicating this enzyme to be the target for its antiamebic action. This enzyme was, however, not inhibited by sinefungin, suggesting an alternative target for growth inhibition by this compound.
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