Knob Antigen Deposition in Cerebral Malaria

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  • * Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106
  • | Department of Medical Research, Ministry of Health, Rangoon, Burma
  • | The Agouron Institute, La Jolla, California 92037

Plasmodium falciparum-infected erythrocytes attach to the endothelial cells via electron-dense knobs and this attachment has been suggested as one of the contributing factors in the development of cerebral malaria. Monoclonal antibodies against an 80–95 Kd knob protein were prepared and applied to brain tissue from cerebral malaria patients. The deposition of the 80–95 Kd knob protein antibodies was observed in the basement membrane of cerebral capillaries by the peroxidase anti-peroxidase method. This result indicates involvement of knob protein deposition in the pathogensis of cerebral malaria.