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Knob Antigen Deposition in Cerebral Malaria
Ikuo Igarashi
Ikuo Igarashi
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106
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Maung Maung Oo
Maung Maung Oo
Department of Medical Research, Ministry of Health, Rangoon, Burma
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Harold Stanley
Harold Stanley
The Agouron Institute, La Jolla, California 92037
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Robert Reese
Robert Reese
The Agouron Institute, La Jolla, California 92037
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Masamichi Aikawa
Masamichi Aikawa
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106
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Plasmodium falciparum-infected erythrocytes attach to the endothelial cells via electron-dense knobs and this attachment has been suggested as one of the contributing factors in the development of cerebral malaria. Monoclonal antibodies against an 80–95 Kd knob protein were prepared and applied to brain tissue from cerebral malaria patients. The deposition of the 80–95 Kd knob protein antibodies was observed in the basement membrane of cerebral capillaries by the peroxidase anti-peroxidase method. This result indicates involvement of knob protein deposition in the pathogensis of cerebral malaria.
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| Past two years | Past Year | Past 30 Days | |
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